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Angiogenesis: bFGF and VEGF in breast carcinoma
Vujasinovi？ Tijana,Buta Marko,Marki？evi？ Milan,Nikoli？-Vukosavljevi？ Dragica
Archive of Oncology , 2006, DOI: 10.2298/aoo0604126v
Abstract: Angiogenesis, or neovascularization, is a complex process leading to formation of new blood vessels from the pre-existing vascular network of the tissue. Angiogenesis plays a central role in various physiological and pathological conditions, including embryonic development, reproduction, inflammation and wound healing, infertility, heart diseases, ulcers, rheumatoid arthritis, diabetic blindness and cancer. It is a multistep process involving EC activation, basement membrane and extracellular matrix (ECM) degradation, EC proliferation, migration and differentiation, synthesis of new basement membrane and maturation of new blood vessels. Tumor vasculature is considered to be of an "immature" nature with series of structural abnormalities. There are reciprocal paracrine interactions between ECs, tumor cells, stroma and ECM. Angiogenesis plays a key role in transformation of normal to malignant cell, tumor progression and metastasis. It is similar to the metastatic process in that it requires EC attachment, proteolysis, and locomotion to proceed. A close relationship exists between the tumor and ECs invasiveness of the tissue. The switch to the angiogenic phenotype involves a change in the local equilibrium between positive and negative regulators of the growth of microvessels. Basic fibroblast growth factor (bFGF) and vas-cular endothelial growth factor (VEGF) are positive regulators of angiogenesis. Intimate cross-talk exists among bFGF and the different members of the VEGF family during angiogenesis, lymphangiogenesis, and vasculogenesis. A substantial body of experimental evidence supports the hypothesis that angiogenesis and angiogenic factors may be strong prognostic and predictive factors in breast carcinoma. This article reviews the current knowledge on angiogenesis and its positive regulators: bFGF and VEGF. .
Right thyroid hemiagenesis with adenoma and hyperplasia of parathyroid glands -case report
Oruci Merima,Ito Yasuhiro,Buta Marko,Radisavljevic Ziv
BMC Endocrine Disorders , 2012, DOI: 10.1186/1472-6823-12-29
Abstract: Background Thyroid hemiagenesis is a rare anomaly, more commonly seen on the left side (ratio 4:1) and in females (ratio 3:1). The first to describe this anomaly was Handfield Jones in 1852. Case presentation We present a 66 year old female patient with right thyroid hemiagenesis, parathyroid adenoma on the side of hemiagenesis and parathyroid hyperplasia on the contralateral side. The patient had neck pain and was diagnosed as Hashimto thyroiditis with hyperparathyroidism. Parathyroid hormone, thyroglobulin antibodies (Tg-Ab) and thyroid peroxidase antibodies (TPO-Ab) were elevated. Neck ultrasound and technetium 99mTc-methoxyisobutyl isonitrile (MIBI) scintigraphy confirmed the right thyroid hemiagenesis, but not adenoma of parathyroid glands. Intraoperatively, right thyroid hemiagenesis was confirmed and left loboistmectomy was performed with removal of left inferior hyperplastic parathyroid gland. Postoperative PTH (parathyroid hormone) levels were within normal range. Five months after the operation PTH level was elevated again with calcium values at the upper limit. MIBI scintigraphy was performed again which showed increased accumulation of MIBI in the projection of the right parathyroid gland. Surgical reexploration of the neck and excision of the right upper parathyroid adenoma was performed which was located behind cricoid laryngeal cartilage. After surgery a normalization of calcium and PTH occured. Conclusion From available literature we have not found the case that described parathyroid adenoma on the side of thyroid hemiagenesis,with parathyroid hyperplasia on the contralateral side.
Breast cancer metastasis to the conjunctiva
Bobi？-Radovanovi？ Anica,Ra？i？ Dejan,Buta Marko,D？odi？ Radan
Vojnosanitetski Pregled , 2013, DOI: 10.2298/vsp120322040b
Abstract: Introduction. Conjunctival metastasis is exceedingly rare, and it is, as a rule, a sign of advanced malignant disease with poor prognosis. We presented a female patient with breast cancer metastasis to the conjunctiva. Case report. A 45-yearold premenopausal female patient was presented with a solitary, yellowish, thin, demarcated lesion in the superior nasal quadrant of the bulbar conjunctiva of the left eye noted by chance a week earlier. There was no sign of irritation, and no pain, and no other functional or morphological problem in either eye or orbit. Five years before the appearance of conjunctival metastasis, breast carcinoma was diagnosed and the patient underwent chemotherapy, preoperative radiotherapy and radical mastectomy. Three years later, computed tomography scan showed metastasis in the left hepatic lobe with ascites and the patient underwent chemotherapy again. But, four months prior to the appearance of conjunctival lesion body scintigraphy showed multifocal sceletal lesions and nuclear magnetic resonance revealed diffuse hepatic metastases and bilateral ovarial tumors. Paliative radiotherapy and hormonal therapy (megestrol, 160 mg) were carried out. An excisional biopsy of the observed conjunctival lesion was performed under topical anesthesia and the material was subjected to histopathological (HP) examination. HP and immunohistochemical examinations established the presence of breast infiltrating lobular carcinoma metastatic to the conjunctiva. The patient showed rapid deterioration after intervention, and died after three weeks. Conclusion. A survival period less than one month after the appearance of conjunctival metastasis deserves attention because it is unexpected and has never been reported previously. It is not a rule that HP presentation of a metastatic lesion is so characteristic that it is possible to determine a primary tumor.
Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature
Radan Dzodic, Boban Stanojevic, Vladimir Saenko, Masahiro Nakashima, Ivan Markovic, Gordana Pupic, Marko Buta, Momcilo Inic, Tatiana Rogounovitch, Shunichi Yamashita
Diagnostic Pathology , 2010, DOI: 10.1186/1746-1596-5-17
Abstract: This case shows that even though benign proliferative change in ectopic breast tissue is an extremely rare phenomenon, this possibility should be taken into account for correct diagnosis.Metastasis of breast cancer is most frequently found in axillary lymph nodes (ALN) [1]. In order to avoid overtreatment of patients, various benign lesions must be clearly differentiated from malignancy. Among the benign conditions, the presence of ectopic breast tissue (EBT) due to embryological displacement within ALN is an uncommon but well-recognized phenomenon [2]. Usually, the nodal EBT inclusion presents with a single or arranged in small clusters normal glandular structures sometimes associated with cystic changes. The presence of a benign proliferative lesion arising in ectopic duct epithelium is exceptionally rare [3]. In this report we present a case intraductal papilloma (IDP) in ALN of a patient who had been treated for IDP of the breast 10 years before.A 34 year-old woman previously operated for a solitary encapsulated papillary thyroid microcarcinoma in the right lobe of the gland, without familial history of breast or thyroid malignancy, was admitted to the Institute of Oncology and Radiology of Serbia, Belgrade, after feeling soreness at breast self-examination followed by a suspicious mammographic finding in the left breast. A lump measuring 30 × 30 × 20 mm in size was surgically removed. Grossly, the resected specimen featured a cyst (15 mm in diameter) with an intracystic proliferative lesion 10 × 10 × 8 mm in size. Histopatholological examination revealed an intracystic IDP without evidence of malignancy (Figure 1). No axillary lymphadenopathy was found at the time of surgery. Whereas no changes were seen in the patient's breast on ultrasound or mammography during follow-up, an enlarged lymph node became palpable in the left axilla 10 years later. A metastatic carcinoma in ALN was suspected and the patient was subjected to excisional biopsy.A lymph node sized 15
THE SWOT ANALYSIS IN THE GEOGRAPHICAL RESEARCH, WITH APPLICABILITY IN THE STUDY OF THE HUMAN SETTLEMENTS FROM MOLDOVA VALLEY - (BAIA-DRAGUSENI SECTOR)
Romic？ Buta
Present Environment and Sustainable Development , 2007,
Abstract: L’analyse SWOT est une méthode efficace, utilisée dans le cas des planifications stratégiques pour l’identification des potentiels, des priorités et pour créer une vision commune de réalisation de la stratégie de développement d’une zone. En fait l’analyse SWOT doit répondre à la question où sommes-nous”, cela impliquant l’analyse du milieu interne et externe spécifique. La valeur de l’analyse SWOT consiste dans le fait qu’elle est une méthode intuitive d’organisation d’une grande quantité d’informations et de données et de leur large applicabilité et c’est une technique par laquelle on peut identifier les points forts et les points faibles et on peut examiner les opportunités et les difficultés d’un projet, d’une action où d’une situation réelle. Elle est extrêmement utile pour les études géographiques aussi, surtout pour celles qui s’occupent de l’analyse socio économique, de l’environnement, de la population, de la planification du développement du territoire et des études géographiques complexes. L’analyse SWOT c’est, enfin, l’identification des atouts, des déficiences (déterminées par le milieu interne), des opportunités et des menaces (déterminés par des facteurs externes : sociaux,technologiques, économiques, écologiques et politiques). Dans le cas concret d’une étude de développement durable d’une zone rurale située au contact entre le Plateau et les Sous Carpates de la Moldavie, nous avons appliqué l’analyse SWOT pour conna tre l’état du milieu naturel et des conditions nécessaires pour le développement cette zone où l’agriculture est la principale activité économique.Dans l’analyse SWOT on a introduit des éléments provenus du remaniement des données statistiques, des études sur le vif, l’interprétation des données cueillies à l’intermédiaire de questions adressées aux habitants et aux représentants de l’autorité locale, l’analyse des cartes topographi
Performance Evaluation and Electromagnetic Compatibility Measurements on UHF Radio Frequency Identification Systems
Georgiana Buta
DOCT-US , 2010,
Abstract: The history of RFID (Radio Frequency IDentification) can be traced back to World War II, when Germans, Japanese, Americans and British were using radar systems to detect the approaching planes while they were miles away. Nowadays, RFID technology is used in a large field of applications like asset tracking, manufacturing and supply chain automation, automotive and contactless payments. Several electromagnetic compatibility measurements on an UHF (865 MHz - 945 MHz) RFID system were performed, while the radiated emissions levels were recorded using a 20 Hz-26.5 GHz EMI Test Receiver, a log-periodic antenna and RF cables. The tests were made in a semi-anechoic chamber, which is a shielded enclosure with radio absorbing material on ceiling and walls
Unilateral follicular variant of papillary thyroid carcinoma with unique KRAS mutation in struma ovarii in bilateral ovarian teratoma: a rare case report
Boban Stanojevic, Radan Dzodic, Vladimir Saenko, Zorka Milovanovic, Vesna Krstevski, Petar Radlovic, Marko Buta, Bozidar Rulic, Lidija Todorovic, Bogomir Dimitrijevic, Shunichi Yamashita
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-224
Abstract: We report 35-year-old woman with bilateral ovarian cysts incidentally detected by ultrasound during the first trimester of pregnancy. Four months after delivery of a healthy child without complication she was admitted to the hospital for acute abdominal pain. Laparoscopic left adnexectomy was performed initially in a regional hospital; right cystectomy was done later in a specialized clinic. Intraoperative frozen section and a final pathology revealed that the cyst from the left ovary was composed of mature teratomatous elements, normal thyroid tissue (>50%) and a non-encapsulated focus of follicular variant of papillary thyroid carcinoma (PTC).Normal and cancerous thyroid tissues were tested for BRAF and RAS mutations by direct sequencing, and for RET/PTC rearrangements by RT-PCR/Southern blotting. A KRAS codon 12 mutation, the GGT？→？GTT transversion, corresponding to the Gly？→？Val amino acid change was identified in the absence of other genetic alterations commonly found in PTC.To the best of our knowledge, this is the first time this mutation is described in a papillary thyroid carcinoma arising in struma in the ovarii. This finding provides further evidence that even rare mutations specific for PTC may occur in such tumors. Molecular testing may be a useful adjunct to common differential diagnostic methods of thyroid malignancy in SO.
Protectionism and “Infant” Industries. Theoretical Approaches
Rozalia KICSI,Simona BUTA
Annals of Dun？rea de Jos University. Fascicle I : Economics and Applied Informatics , 2010,
Abstract: For many centuries, the customs duties, the quantitative restrictions and other similar stipulations have represented the instruments specific to historical progress of any countries, from one moment of time to another; such instruments were emphasized either by increasing the revenues, by supporting the development of some areas, thus protecting them against to foreign competition, or by other reasons. The protectionist systems have had followers within all structures of the society, where each of them have brought substantiations dictated by own faith or interests.
TRADE NAME, FIRM, DENOMINATION SOCIALE AND RAISON SOCIALE. ARE THEY ALL THE SAME?
PAUL-GEORGE BUTA
Challenges of the Knowledge Society , 2013,
Abstract: The present study intends to point out the different designations used to indicate business identifiers and verify whether they facilitate the minimization of the two types of transaction costs usually mitigated by such identifiers. Even when the Paris Convention for the Protection of Industrial Property was being drafted in the 19th century there were ample debates regarding the need for an international protection for trade names. And even then the reports presented to the Congress then mentioned the fact that national protection for trade names was provided for under various designations and with different scope in the countries that were analyzed. Since the determination of the various designations used has as its starting point the provisions of the Paris Convention an analysis starting from the designations used in France is necessary. A comparison with the terms used in Germany and France is then provided so as to offer a wide array of models for business identifiers that are to be later assessed as against their ability to mitigate transaction costs.
SHORT CONSIDERATIONS ON THE USE OF TRADE INDICATORS AS TRADEMARKS
PAUL-GEORGE BUTA
Challenges of the Knowledge Society , 2012,
Abstract: In today's global marketplace products and services are exchanged internationally not only by large companies wielding a large portfolio of internationally protected trademarks but also by small enterprises and even individuals who have neither the resources nor an interest in the building of such a portfolio. Since they are nonetheless economic agents using either their own or others' trade indicators to indicate the origin and quality of the products and services they provide or simply to advertise them, the present paper addresses some of the issues arising out of that use which is akin to trademark use in what regards said products and services. Special attention is paid to the change in purpose of the trade indicators when used as trademarks and the effects said change causes in the legal protection conferred to those trade indicators. Moreover the possible conflicts between such rights are shortly analyzed and the means for resolution of such conflicts briefly reviewed. Far from being an exhaustive study of the issues raised the present paper aims at identifying these issues and pointing to contentious points to be addressed by future research.
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